Optimized synthesis of 2-substituted 1-halocyclopropane-1-carboxylic acids

Autor:	A. V. Zorin, Almaz Zagidullin, V. V. Zorin
Rok vydání:	2016
Předmět:	In situ Argon 010405 organic chemistry Chemistry Inorganic chemistry Salt effect chemistry.chemical_element General Chemistry 010402 general chemistry n-Butyllithium 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Carboxylation Lithium chloride
Zdroj:	Russian Journal of General Chemistry. 86:2307-2311
ISSN:	1608-3350 1070-3632
Popis:	The reaction of gem-dichloro- and gem-dibromocyclopropanes with n-butyllithium in THF under argon at–78°С followed by purging the reaction mixture with dry CO2 was used to synthesize cis- and/or trans-1-halocyclopropane-1-carboxylic acids in 30–56% yields. The yields of the target products could be increased to 76–83% by the addition of an equimolar amount of LiCl to the reaction mixture. The highest salt effect was obtained with lithium chloride generated in situ (88–96%).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::488c81022fb6a7b96b4248c06bb157dc https://doi.org/10.1134/s1070363216100108 Zobrazit plný text záznamu Plný text ve formátu PDF