New Acylate and Thioacylate Effectors of Mammalian Cholinesterases Based on Cyclic Ammonium Alcohols Containing Elements of the Anabasine Structure
| Autor: | A. A. Suvorov, A. Yu. Perchenok, N. E. Basova, Vladimir S. Saakov, B. N. Kormilitsyn, E. V. Rozengart |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Physiology Stereochemistry Effector Anabasine Biochemistry 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Enzyme chemistry Ammonium Erythrocyte cholinesterase 030217 neurology & neurosurgery Ecology Evolution Behavior and Systematics Butyrylcholinesterase Alkyl |
| Zdroj: | Journal of Evolutionary Biochemistry and Physiology. 54:22-29 |
| ISSN: | 1608-3202 0022-0930 |
| DOI: | 10.1134/s0022093018010039 |
| Popis: | We report a pioneering analysis of the interaction between mammalian cholinesterases and 36 acylates and thioacylates of ammonium alcohols with different structure of an alkyl chain between ammonium and etheric atoms and with different structure of a cyclic ammonium group. Among these ethers, which were both substrates and reversible inhibitors of erythrocyte cholinesterase and serum butyrylcholinesterase, specific effectors of both enzymes were identified. |
| Databáze: | OpenAIRE |
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