Continuous Infusion of β-Amyloid Protein into the Rat Cerebral Ventricle Induces Learning Impairment and Neuronal and Morphological Degeneration

Autor:	Marina R. Grigorian, Karen S. Toumasian, Sergey E. Akopov, E. Gabrielian
Rok vydání:	1997
Předmět:	Pharmacology Pathology medicine.medical_specialty CATS biology business.industry Fissipedia Brain damage biology.organism_classification medicine.disease Thrombosis Blood cell medicine.anatomical_structure Cerebrospinal fluid In vivo Medicine Platelet medicine.symptom business
Zdroj:	Japanese Journal of Pharmacology. 73:51-57
ISSN:	0021-5198
DOI:	10.1254/jjp.60.51
Popis:	Ischemia-like brain damage was induced in cats by selective injection of 4β-phorbol-12β-myristate-13α-acetate (PMA) into the left carotid artery. PMA-injection provoked significant decreases in platelet and neutrophil counts due to their intravascular aggregation. Platelet and neutrophil aggregates caused brain edema with accumulation of sodium fluorescein in the cerebrospinal fluid and ipsi-lateral derangement of the cerebral energy state in the parietal cortex. Neurotropin administration decreased the changes in platelet and neutrophil counts and prevented the developments of both brain edema and cerebral energy failure.
Databáze:	OpenAIRE
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