Expanding the effectiveness of screening

Autor:	Minsoo Song, Gil Tae Hwang
Rok vydání:	2021
Předmět:	ComputingMethodologies_PATTERNRECOGNITION 010405 organic chemistry Chemistry Drug discovery General Chemical Engineering General Chemistry Computational biology Living cell 010402 general chemistry Ligand (biochemistry) 01 natural sciences 0104 chemical sciences
Zdroj:	Nature Chemistry. 13:515-517
ISSN:	1755-4349 1755-4330
DOI:	10.1038/s41557-021-00690-6
Popis:	DNA-encoded libraries are a powerful tool to identify hit compounds for drug discovery. Now, two papers have reported new advances in this technology. One paper reports a method to screen for binders inside a living cell, and the other investigates the effects of stereo- and regiochemistry on ligand discovery.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4877d02e9bbebbc496cefb6ced62f72b https://doi.org/10.1038/s41557-021-00690-6 Zobrazit plný text záznamu Full text from SpringerLink