Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease

Autor:	L. P. Lazarou, Jeremy Peter Cheadle, Marcy E. MacDonald, James F. Gusella, Peter Davies, I. Fenton, J C MacMillan, Peter S. Harper, Russell G. Snell, D.J. Shaw
Rok vydání:	1993
Předmět:	Genetics Huntington's disease Genetic variation medicine Chromosome Disease Allele Biology medicine.disease Trinucleotide repeat expansion Gene Phenotype
Zdroj:	Nature Genetics. 4:393-397
ISSN:	1546-1718 1061-4036
DOI:	10.1038/ng0893-393
Popis:	The molecular analysis of a specific CAG repeat sequence in the Huntington's disease gene in 440 Huntington's disease patients and 360 normal controls reveals a range of 30-70 repeats in affected individuals and 9-34 in normals. We find significant negative correlations between the number of repeats on the HD chromosome and age at onset, regardless of sex of the transmitting parent, and between the number of repeats on the normal paternal allele and age at onset in individuals with maternally transmitted disease. This effect of the normal paternal allele may account for the weaker age at onset correlation between affected sib pairs with disease of maternal as opposed to paternal origin and suggests that normal gene function varies because of the size of the repeat in the normal range and a sex-specific modifying effect.
Databáze:	OpenAIRE
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