Selective regulation of dopamine transporter binding in the shell of the nucleus accumbens by adrenalectomy and corticosterone‐replacement
| Autor: | Christina R. McKittrick, Mary Jeanne Kreek, Zoltán Sarnyai, Bruce S. McEwen |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
biology Addiction media_common.quotation_subject Adrenalectomy medicine.medical_treatment Nucleus accumbens Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology chemistry Dopamine Corticosterone Internal medicine biology.protein medicine Chronic stress Psychology Neuroscience hormones hormone substitutes and hormone antagonists Glucocorticoid media_common Dopamine transporter medicine.drug |
| Zdroj: | Synapse. 30:334-337 |
| ISSN: | 1098-2396 0887-4476 |
| DOI: | 10.1002/(sici)1098-2396(199811)30:3<334::aid-syn11>3.0.co;2-# |
| Popis: | [Extract] Chronic stress or high glucocorticoid levels have been shown to affect fundamental brain functions, including emotions, cognition, and reward/reinforcement, and may be associated with psychiatric disorders (McEwen, 1998; Piazza and LeMoal, 1997). Stress and glucocorticoids (GCs) have also been suggested as major factors influencing drug addiction (Kreek, 1996; Piazza and LeMoal, 1997). For example, chronic stress increases the vulnerability to develop psychostimulant selfadministration in a glucocorticoid-responsive manner (for a review, see Piazza and LeMoal, 1997). Moreover, rats have been shown to intravenously self-administer corticosterone (CORT) (see Piazza and LeMoal, 1997), which suggests an important role of CORT in reward related brain processes. |
| Databáze: | OpenAIRE |
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