Tumor MK2 transcript levels are associated with improved response to chemotherapy and patient survival in non-small cell lung cancer

Autor:	Karthik Suresh, Othello Del Rosario, Medha Kallem, Gayatri Singh, Anika Shah, Linda Zheng, Xin Yun, Nicolas M. Philip, Nirupama Putcha, Marni B. McClure, Haiyang Jiang, Franco D’Alessio, Meera Srivastava, Alakesh Bera, Larissa A. Shimoda, Michael Merchant, Madhavi J. Rane, Carolyn E. Machamer, Jason Mock, Robert Hagan, Abigail L. Koch, Naresh M. Punjabi, Todd M. Kolb, Mahendra Damarla
Rok vydání:	2023
Předmět:	Physiology Genetics
Zdroj:	Physiological Genomics. 55:168-178
ISSN:	1531-2267 1094-8341
DOI:	10.1152/physiolgenomics.00155.2022
Popis:	MK2, known to promote caspase-3 nuclear translocation in the execution of apoptosis, is reduced in non-small cell lung cancer cells. In adenocarcinomas of patients, higher MK2 expression is associated with early-stage disease, better clinical response following chemotherapy and independently associated with improved survival.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4858e57e9d5950f2a285f4ab23fa97ee https://doi.org/10.1152/physiolgenomics.00155.2022 Zobrazit plný text záznamu