Design and Analysis of a Microwave-Optical Dual Modality Biomolecular Sensing Platform
| Autor: | Luya Zhang, Ali M. Niknejad |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Photon
Materials science business.industry Oscillation 020208 electrical & electronic engineering Physics::Optics 02 engineering and technology Noise (electronics) CMOS Phase noise 0202 electrical engineering electronic engineering information engineering Optoelectronics Sensitivity (control systems) Electrical and Electronic Engineering business Microwave Diode |
| Zdroj: | IEEE Journal of Solid-State Circuits. 55:639-649 |
| ISSN: | 1558-173X 0018-9200 |
| Popis: | A combined microwave-optical biomolecular sensor with high sensitivity and selectivity is presented. The microwave sensor characterizes the dielectric properties of a medium using the oscillation frequency shift. To improve the sensor sensitivity beyond the 1/ $ {f^{{3}}}$ phase noise limit, a quadrature-oscillator-based reactance sensing scheme is proposed, which attenuates the 1/ $ {f^{{3}}}$ noise by 20 dB/decade. Further sensitivity enhancement is realized by a novel chopping technique that modulates the free-running frequencies of the coupled oscillators differentially while maintaining a fixed locking frequency. To achieve a higher selectivity, optical sensors are introduced to target specific biomolecules. Utilizing single-photon avalanche diodes, they detect both photon intensity and photon emission time. A biosensor prototype was fabricated in a 28 nm CMOS technology. The microwave sensor achieves 0.2 ppm/ $\sqrt {\text {Hz}}$ frequency sensitivity with 11.5 mW power consumption. The optical sensor shows 500/s dark count rate and 300 ps timing jitter at 1 V excess bias. A protein thermal denaturation experiment confirms the sensitivity and selectivity enhancement of the dual-modality biosensing platform. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|