The effect of polyhydramnios degree on chromosomal microarray results: a retrospective cohort analysis of 742 singleton pregnancies
| Autor: | Lena Sagi-Dain, Idit Maya, Michal Feingold-Zadok, Shay Ben Shachar, Amihood Singer, Anat Bar-Shira, Tzipora C. Falik-Zaccai, Amir Peleg |
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| Rok vydání: | 2021 |
| Předmět: |
Polyhydramnios
medicine.medical_specialty Fetus 030219 obstetrics & reproductive medicine medicine.diagnostic_test Microarray business.industry Obstetrics Ultrasound Obstetrics and Gynecology Prenatal diagnosis Retrospective cohort study General Medicine medicine.disease 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Cohort medicine business Fetal echocardiography |
| Zdroj: | Archives of Gynecology and Obstetrics. 304:649-656 |
| ISSN: | 1432-0711 0932-0067 |
| DOI: | 10.1007/s00404-021-05995-y |
| Popis: | To analyze the risk for clinically significant microarray aberrations in pregnancies with polyhydramnios. Data from all chromosomal microarray analyses (CMA) performed due to polyhydramnios between January 2013 and December 2019 were retrospectively obtained from the Ministry of Health Database. The rate of clinically significant (pathogenic and likely pathogenic) CMA findings in isolated and non-isolated polyhydramnios cohorts was compared to a local control group of 5541 fetuses with normal ultrasound, in which 78 (1.4%) abnormal results were demonstrated. Subgroup analyses were performed by the degree of polyhydramnios, week of diagnosis, maternal age, and the presence of additional sonographic anomalies. In the isolated polyhydramnios cohort, 19/623 (3.1%) clinically significant CMA aberrations were noted, a significantly higher rate compared to the control population. However, the risk for abnormal CMA results in the 158 cases with mild polyhydramnios (AFI 25–29.9, or maximal vertical pocket 8–11.9 cm) did not significantly differ from pregnancies with normal ultrasound. Of 119 cases of non-isolated polyhydramnios (most frequently associated with cardiovascular (26.1%) and brain (15.1%) anomalies), 8 (6.7%) abnormal CMA findings were noted, mainly karyotype-detectable. Mild polyhydramnios was not associated with an increased rate of clinically significant microarray results, compared to pregnancies with normal ultrasound. An extensive anatomical sonographic survey should be performed in pregnancies with polyhydramnios, with consideration of fetal echocardiography. |
| Databáze: | OpenAIRE |
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