Synthesis of 4-Amino-8-(2, 2-Difluoro-2-Deoxy-β-D-Ribo Furanosyl Amino)Pyrimido [5, 4-D]Pyrimidine (dFARPP). Stability and Cellular Cytotoxicity

Autor:	H. L. Pearce, J. M. Colacino, Chou Ta-Sen, C. D. Jones, T. E. Mabry, G. B. Grindey, J. F. Worzalla
Rok vydání:	1994
Předmět:	Glycosylamine Purine Anomer Pyrimidine Stereochemistry RNA Biological activity Biochemistry chemistry.chemical_compound chemistry Genetics Mitsunobu reaction DNA
Zdroj:	Nucleosides and Nucleotides. 13:1125-1133
ISSN:	0732-8311
Popis:	The synthesis of β-dFARPP was accomplished by Mitsunobu coupling of 6-cyanopurine with 2-deoxy-2, 2-difluororibose followed by purine ring-expansion under the action of methanolic ammonia. The title compound inhibited the growth of proliferating human leukemic CCRF-CEM cells at 6.1μg/ml but had no effect on plaque formation by a variety of DNA and RNA viruses.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::484699880d228ed1e5eddc7dcc437040 https://doi.org/10.1080/15257779408011883 Zobrazit plný text záznamu