The antioxidant and membrane-stabilizing properties of 1-(4-substituted phenyl)-2h-(phenyl)-3-aminopropan-1-ol hydrochlorides in vitro

Autor:	O. A. Papoyan, S. A. Badzhinyan, L. A. Vardevanyan, M. G. Malakyan, A. U. Isakhanyan, G. A. Gevorgyan
Rok vydání:	2011
Předmět:	Pharmacology Antioxidant Chemistry medicine.medical_treatment Biological activity medicine.disease_cause In vitro In vitro model Membrane Drug Discovery medicine Organic chemistry Aminopropanols Oxidative stress Analysis method
Zdroj:	Pharmaceutical Chemistry Journal. 44:591-593
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-011-0523-0
Popis:	In vitro model systems were used to study the antioxidant and membrane-stabilizing properties of 1-(4-substituted phenyl)-2H-(phenyl)-3-aminopropan-1-ol hydrochlorides. These secondary aminopropanols, whose synthesis is first reported here, were found not to have any significant antioxidant or antiradical activity either in an ascorbate-dependent Fe(II)-stimulated peroxidation system, in a method based on the spectrophotometric monitoring of decreases in the concentration of the stable radical 1,1-diphenyl-2-picrylhydrazyl, or in the photochemiluminescence analysis method. However these compounds had marked antihemolytic effects in an erythrocyte oxidative stress model. It is suggested that the new 1-(4-substituted phenyl)-2H-(phenyl)-3-aminopropan-1-ol hydrochlorides are biologically active compounds with weak antioxidant properties, capable of membrane-stabilizing actions due to interaction with the structural components of cell membranes.
Databáze:	OpenAIRE
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