Purging of Bone Marrow with the B-Lymphocyte Specific Monoclonal Antibody Y29/55 and Complement: Exclusion of Antigenic Modulation

Autor:	U. Bucher, Andreas Morell, H. P. Wagner, Angelika C. Stern, C. Baumgartner, G. P. Brun del Re, Andreas Hirt, H. K. Forster
Rok vydání:	1985
Předmět:	biology medicine.drug_class Chemistry Chronic lymphocytic leukemia Lymphocyte Monoclonal antibody medicine.disease Lymphoma Transplantation medicine.anatomical_structure immune system diseases hemic and lymphatic diseases Immunology medicine biology.protein Antigenic Modulation Bone marrow Antibody
Zdroj:	11th Annual meeting of the EBMT ISBN: 9783662393994
DOI:	10.1007/978-3-662-40457-7_38
Popis:	The murine monoclonal antibody (mAB) anti-Y 29/55 (IgG2A) reacts with malignant B-lymphocytes obtained from patients with chronic lymphocytic leukemia (CLL) or non-Hodgkin’s-lymphoma (NHL) (1). We have used this antibody for in vitro complement (C’) induced elimination of lymphoma cells in human bone marrow (b.m.) prior to autologous b.m. transplantation (2). Certain mAB are known to induce antigenic modulation. This could interfere with optimal C’-mediated cell lysis (3). Optimal incubation conditions have been defined with CLL-cells
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4832893d9fbb2eae93cdc79fc3e4eb37 https://doi.org/10.1007/978-3-662-40457-7_38 Zobrazit plný text záznamu