Isolation of an Intermediate in the Platination of p ‐Nitroacetophenone 4‐Methylthiosemicarbazone: Potential Application as an Antitumor Drug

Autor:	Amancio Carnero, Carmen Navarro-Ranninger, Leticia Cubo, Victoria Moneo, Adoración G. Quiroga, Pablo J. Sanz Miguel
Rok vydání:	2008
Předmět:	Inorganic Chemistry chemistry.chemical_compound Chemistry Stereochemistry Ligand P-nitroacetophenone chemistry.chemical_element Reactivity (chemistry) Crystal structure Nci h460 Platinum Semicarbazone Palladium
Zdroj:	European Journal of Inorganic Chemistry. 2008:1183-1187
ISSN:	1099-0682 1434-1948
DOI:	10.1002/ejic.200800003
Popis:	The investigation of the formation and reactivity of Pd and Pt thiosemicarbazone complexes has revealed an unstudied intermediate derived from p-nitroacetophenone 4-methylthiosemicabazone (L1H2). The L1H2 ligand leads to a new complex [Pt(L1)(L1H2)] that supports the postulated mechanism of how cyclometallation reactions take place. All the newly synthesized complexes, [(Pd(L1)4], [(Pt(L1)4], and [Pt(L1)(L1H2)] (3), have been characterized and tested against MCF7, SF268, and NCI H460 cell lines. The crystal structure of [Pt(L1)(L1H2)]·dmso is reported. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Databáze:	OpenAIRE
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