Disulfide bond cleavage in neutral substrates by the dimethylene ketene radical cation inside a mass spectrometer

Autor:	D. Tutko, Hilkka I. Kenttämaa, James Pérez, Rebecca L. Smith, Kami K. Thoen
Rok vydání:	1998
Předmět:	chemistry.chemical_compound Radical ion Chemistry Disulfide bond Ketene Cleavage (crystal) Distonic ion Mass spectrometry Photochemistry Derivatization Spectroscopy Ion cyclotron resonance
Zdroj:	International Journal of Mass Spectrometry and Ion Processes. 175:173-177
ISSN:	0168-1176
Popis:	The reactivity of the dimethylene ketene radical cation (a distonic ion) toward organic disulfides was examined inside a Fourier-transform ion cyclotron resonance mass spectrometer. The radical cation efficiently cleaves the disulfide bond in all the disulfides studied. Hence, this radical cation provides a potentially useful tool for the mass spectrometric characterization and location of disulfide bonds in neutral substrates without the requirement of prior derivatization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::480bb321f72446b6ef7a1f87f93cbc31 https://doi.org/10.1016/s0168-1176(98)00116-5 Zobrazit plný text záznamu Full Text from ScienceDirect