Forecasting the course of occupational chronic fl uorine intoxication by means of univariate analysis
| Autor: | O. G. Shmonina, K. S. Kudrinа, V. B. Gurvich, Ye. A. Kovin, T. Yu. Obukhova, A. A. Fedoruk, L. N. Budkar, S. I. Solodushkin |
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| Rok vydání: | 2019 |
| Předmět: |
Metabolic state
medicine.medical_specialty Univariate analysis business.industry Disease outcome Occupational disease Retrospective cohort study General Medicine medicine.disease 030210 environmental & occupational health 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Length of service 030212 general & internal medicine business Analysis method |
| Zdroj: | Occupational Health and Industrial Ecology. :80-85 |
| ISSN: | 2618-8945 1026-9428 |
| DOI: | 10.31089/1026-9428-2019-2-80-85 |
| Popis: | Relevance. In contemporary occupational pathology, diagnosis of occupational fluorosis is based on locomotory apparatus disorder such as fluorine osteopathy. Other significant consequences of negative effects of fluorine compounds are deactivation of enzymatic systems, metabolic disorders — that results in pathologic involvement of many organs and systems (hepato-biliary, cardiovascular, respiratory, nervous, endocrine, gastrointestinal). Topical issue is search of a complex of factors influencing development of the occupational disease, to optimize management of occupational fluorine intoxication risk.Objective. To determine spectrum of factors that promote development of occupational fl uorine intoxication in workers exposed to inorganic fl uorine compounds, for forecasting the disease outcome and selecting main trends of preventive measures.Materials and methods.Single-factor analysis methods helped to carry retrospective cohort study of occupational fl uorine intoxication development in 201 workers of aluminum production in Ural region. Th e study covered infl uence of main occupational factors and somatic health parameter s on occupational fl uorosis development.Results.Findings are reliable infl uence of age (k=0.532, pConclusion.Using single-factor analysis helped to determine wide spectrum of factors associated with the workers’ health state and work conditions, that signifi cantly infl uence development of fl uorine intoxication. Th e authors proved that period of occupational chronic fl uorine intoxication is notably infl uenced by occupational factors (length of service, hydrofl uoride level, fl uorine load degree, magnetic fi eld) and somatic state characteristics as age, parameters of carbohydrate, lipid, purine metabolism, status of cardiovascular, excretory systems, kidneys and gastrointestinal tract functions. |
| Databáze: | OpenAIRE |
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