Granulomatous Vasculitis in Crohn’s Disease

Autor:	A. M. Sawyerr, Peter M. Rowles, Robert M. Pittilo, Andrew J. Wakefield, Adam A. M. Lewis, Linda More, Rosalind Sim, Amar P. Dhillon, Mark Hudson, Elizabeth A. Sankey, Ron E. Pounder
Rok vydání:	1991
Předmět:	Systemic disease Crohn's disease Mean arterial pressure Pathology medicine.medical_specialty Hepatology business.industry Gastroenterology medicine.disease digestive system diseases Pathogenesis medicine.anatomical_structure Granuloma Submucosa medicine Immunohistochemistry Vasculitis business
Zdroj:	Gastroenterology. 100:1279-1287
ISSN:	0016-5085
Popis:	This study investigated a possible vascular origin for granulomas in Crohn's disease. Twenty-four consecutive resected specimens of small and large intestinal Crohn's disease were preserved by arterial perfusion-fixation with 10% formol saline, at mean arterial pressure (100 mm Hg). Fifteen specimens contained granulomas on routine examination of HE they were found most frequently in the submucosa (42%). The techniques used in this study enhanced the recognition of granulomatous vasculitis. The results suggest that the majority of granulomas in Crohn's disease form within walls of blood vessels. Vascular localization of granulomatous inflammation suggests that the intestinal microvasculature contains an early element in the pathogenesis of Crohn's disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::47f698dc47024e6a8d51627353f7358f https://doi.org/10.1016/0016-5085(91)70014-o Zobrazit plný text záznamu