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Background: Hepatitis B virus remains a public health dilemma with a high mortality rate worldwide. Health care providers and health students have garter risk of catching the infection as they are close to infected individuals and their bodily fluids. Consequently, we aimed to estimate the awareness, knowledge, and compliance with the vaccine among health-related students in Makkah, Saudi Arabia. Methods: This analytic cross-sectional study was demonstrated using a self-administered structured survey at Umm Al-Qura University (UQU), Makkah, Saudi Arabia. The study was carried out from March 2021 to September 2021 after obtaining ethical approval from UQU’s research ethics committee. A random sampling technique and multistage stratification method were applied to stratify students Results: Among the studied subjects 354 students of health-related students were surveyed. The mean age of participants was 21.1 ± 2.4 years. The majority of the students were males (286, 80.8%). There were significant differences between students’ demographic data and level of knowledge (p-values, 0.000). Conclusion: This study revealed that the majority of the students reflect positive attitude concerning vaccination compliance. Additionally, participants’ age, gender, college, marital status, and academic year showed a significant relationship with their level of awareness compared with the other demographic categories. |