Pancreatic stem cells: a therapeutic agent that may offer the best approach for curing type 1 diabetes
| Autor: | Janet G. Cornelius, Ammon B. Peck, Vijayakumar K. Ramiya, Monika Chaudhari, Desmond A. Schatz |
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| Rok vydání: | 2001 |
| Předmět: |
geography
Type 1 diabetes geography.geographical_feature_category business.industry Endocrinology Diabetes and Metabolism Pancreatic islets Insulin medicine.medical_treatment Islet medicine.disease medicine.anatomical_structure Immune system Diabetes mellitus Pediatrics Perinatology and Child Health Immunology Internal Medicine medicine Stem cell Pancreas business |
| Zdroj: | Pediatric Diabetes. 2:195-202 |
| ISSN: | 1399-543X |
| Popis: | Chaudhari M, Cornelius JG, Schatz D, Peck AB, Ramiya VK. Pancreatic stem cells: a therapeutic agent that may offer the best approach for curing type 1 diabetes. Abstract: Type 1 (insulin-dependent) diabetes is one of the most costly chronic diseases of children and adolescents in North America and Europe. It occurs in genetically predisposed individuals when the immune system attacks and destroys specifically the insulin-producing beta cells of the pancreatic islets of Langerhans. Although routine insulin injections can provide diabetic patients their daily insulin requirements, non-compliance commonly results in blood glucose excursions that eventually lead to microvascular and macrovascular complications and early death. The only real ‘cure’ for type 1 diabetes is replacement of the beta-cell mass which, today, is either an ectopancreatic transplant or an islet of Langerhans implant. Two new developments may offer additional options: surrogate, non-endocrine cells genetically modified to secrete insulin in response to high blood glucose levels; and stem cells that possess the capacity to differentiate to endocrine pancreas. In this short review, we discuss the efforts currently being made to regulate pancreatic stem cell growth in order to produce large numbers of functional islets that can be used as implants. Hopefully, autologous stem cell-derived islet cell implants without lifelong immunosuppressive therapy may one day be realized. |
| Databáze: | OpenAIRE |
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