A Prospective Study of Hyperparathyroidism in Individuals Exposed to Radiation in Childhood
| Autor: | Arthur B. Schneider, Joel R. Cohen, Theresa C. Gierlowski |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Pediatrics
medicine.medical_specialty education.field_of_study Hyperparathyroidism endocrine system diseases Parathyroid neoplasm business.industry medicine.medical_treatment Incidence (epidemiology) Population General Medicine medicine.disease Radiation therapy medicine business Nuclear medicine Prospective cohort study education Thyroid cancer Cohort study |
| Zdroj: | JAMA: The Journal of the American Medical Association. 264:581 |
| ISSN: | 0098-7484 |
| DOI: | 10.1001/jama.1990.03450050039024 |
| Popis: | To determine the effects of childhood irradiation on the parathyroid glands, a cohort of 4297 patients who received radiation to the tonsils before the age of 16 years has been followed-up prospectively. Among the 2923 patients who were located and provided information, 32 patients developed clinical hyperparathyroidism. The incidence of clinical hyperparathyroidism was 18.7 per 100,000 person-years below the age of 40 years and 171 per 100,000 person-years in the age range of 40 to 60 years. This represents a 2.9-fold (95% confidence interval, 1.6 to 4.3) and 2.5-fold (95% confidence interval, 1.1 to 3.9) increase in the incidence of hyperparathyroidism compared with that among the general population. In addition, 31% of the patients who developed hyperparathyroidism also developed thyroid cancer, which is higher than the 11.2% prevalence of thyroid cancer in the patients who received radiation therapy who did not develop parathyroid tumors. Patients with a history of head and neck irradiation should have their parathyroid glands evaluated on a regular basis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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