Effect of vitamin A administration on response to oral polio vaccination
| Autor: | Mohammad Mijanur Rahman, Demissie Habte, Jose O. Alvarez, George J. Fuchs, Dilip Mahalanabis, Leanne Unicomb, Mohammad A. Wahed, Mohammad Aminul Islam |
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| Rok vydání: | 1998 |
| Předmět: |
Vitamin
medicine.medical_specialty education.field_of_study Nutrition and Dietetics business.industry Endocrinology Diabetes and Metabolism Population medicine.disease Gastroenterology Polio Vaccination Infant nutrition disorder Poliomyelitis Vaccination chemistry.chemical_compound Endocrinology Blood serum chemistry Internal medicine Immunology Medicine Seroconversion business education |
| Zdroj: | Nutrition Research. 18:1125-1133 |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/s0271-5317(98)00094-3 |
| Popis: | To evaluate the effect of simultaneous administration of vitamin A and Oral Polio Vaccine (OPV) on seroconversion to OPV a randomized double-blind, placebo-controlled trial was conducted. Fifty-seven infants were randomly given either 50,000 I.U. vitamin A (n=34) or placebo (n=23) with each OPV vaccine at monthly intervals. Seroconversion to polio were 81% (79% in vitamin A group and 83% in placebo group, p=0.76) for polio virus type 1, 86% (82% in vitamin A group and 91% in placebo group, p=0.34) for polio virus type 2, and 84% (82% in vitamin A group and 87% in placebo group, p=0.64) for polio virus type 3. A multiple logistic regression model was done to examine the factors associated with reduced seroconversion (polio virus type 1). For adequate vitamin A status the adjusted odds ratio of seroconversion was 0.24 (95% CI: 0.04-1.49, p=0.11) and that for high maternal antibody was 0.11 (95% CI: 0.02-0.68, p=0.015). The geometric mean titer (GMT) was significantly lower in infants with adequate vitamin A stores compared to vitamin A deficient infants (p=0.04; Mann-Whitney test). The results of this study suggest that vitamin A supplementation had no effect on seroconversion, however, in children with adequate vitamin A status there was a trend towards lower seroconversion. High maternal antibody was significantly associated with reduced seroconversion to the oral polio vaccine. |
| Databáze: | OpenAIRE |
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