Albumin and water fluxes during cardiopulmonary bypass
| Autor: | C.E. Webber, E.S. Garnett, K.-L. Wong, E. Regoeczi, G. Evans, H.W. Beattie |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Pulmonary and Respiratory Medicine
Oncotic pressure medicine.medical_specialty business.industry Albumin Blood volume Control subjects law.invention Endocrinology law Interstitial fluid Internal medicine Time course Cardiopulmonary bypass Medicine Surgery Specific activity Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 67:926-931 |
| ISSN: | 0022-5223 |
| DOI: | 10.1016/s0022-5223(19)41720-0 |
| Popis: | If cardiopulmonary bypass is done with a hypooncotic prime, the initial fall in colloid osmotic pressure in the patient is followed by an incomplete compensatory rise. The mechanism of this rise has been investigated by studying the time course of the specific activity and the concentration of 125I albumin activity in the plasma. Albumin specific activity fell at a rate greater than that measured in the control subjects, thus indicating an increased influx of albumin into the circulating blood volume. The concentration of labeled albumin in the patients, in sharp contrast to that in the control subjects, rose during bypass. This indicated an efflux of water from the circulating blood volume. It is concluded that both albumin influx and water efflux contribute to the rise in colloid osmotic pressure during bypass. It is further concluded that at the end of bypass approximately 40 per cent of the rapidly exchangeable extravascular albumin pool will have been transferred to the intravascular compartment, while approximately 1 L. of water will have been added to the interstitial fluid. |
| Databáze: | OpenAIRE |
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