Application of one-bead one-structure approach to identification of nonpeptidic ligands

Autor:	O. Issakova, M. Lebl, Kit S. Lam, Nikolai F. Sepetov, Viktor Krchnak, Magda Stankova
Rok vydání:	1994
Předmět:	chemistry.chemical_classification Streptavidin Chemistry Stereochemistry Ligand binding assay Chemical synthesis Combinatorial chemistry Chemical library Amino acid chemistry.chemical_compound Residue (chemistry) Drug Discovery Imidazole Moiety
Zdroj:	Drug Development Research. 33:146-156
ISSN:	1098-2299 0272-4391
Popis:	A synthetic chemical library comprised of alkylated and acylated amino acids was synthesized and screened to determine structures that bind to a model target, streptavidin. The library was prepared using "split synthesis" and screened in a solid phase binding assay. The structure of positively reacting compounds was determined using mass spectroscopy. Positive compounds, together with various structural analogs were synthesized and their binding con- firmed. Structures containing both an imidazole moiety and a substituted aromatic residue dem- onstrated binding. :CI 1994 Wiiey-Liss, Inc.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::47de2834d0a77fd5d52fe80f587f090c https://doi.org/10.1002/ddr.430330211 Zobrazit plný text záznamu Plný text