Diagnostic value of combining 11C-choline and 18F-FDG PET/CT in hepatocellular carcinoma

Autor: Serge Desarnaud, Hélène Agostini, Dominique Franco, Maria-Angéla Castilla-Lièvre, Bertrand Kuhnast, Lysiane Marthey, Philippe Gervais, Badia-Ourkia Helal
Rok vydání: 2015
Předmět:
Zdroj: European Journal of Nuclear Medicine and Molecular Imaging. 43:852-859
ISSN: 1619-7089
1619-7070
DOI: 10.1007/s00259-015-3241-0
Popis: In this prospective study, our goal was to emphasize the diagnostic value of combining 11C-choline and 18F-FDG PET/CT for hepatocellular carcinoma (HCC) in patients with chronic liver disease. Thirty-three consecutive patients were enrolled. All patients were suspected to have HCC based on CT and/or MRI imaging. A final diagnosis was obtained by histopathological examination or by imaging alone according to American Association for the Study of Liver Disease criteria. All patients underwent PET/CT with both tracers within a median of 5 days. All lesions showing higher tracer uptake than normal liver were considered positive for HCC. We examined how tracer uptake was related to biological (serum α-fetoprotein levels) and pathological (differentiation status, peritumoral capsule and vascular invasion) prognostic markers of HCC, as well as clinical observations at 6 months (recurrence and death). Twenty-eight HCC, four cholangiocarcinomas and one adenoma were diagnosed. In the HCC patients, the sensitivity of 11C-choline, 18F-FDG and combined 11C-choline and 18F-FDG PET/CT for the detection of HCC was 75 %, 36 % and 93 %, respectively. Serum α-fetoprotein levels >200 ng/ml were more frequent among patients with 18F-FDG-positive lesions than those with 18F-FDG-negative lesions (p
Databáze: OpenAIRE
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