B cells behaving badly

Autor: Martha S. Linet, Neil E. Caporaso, Dannie C. Middleton, Sharon R. Silver, Gerald E. Marti, Youn K. Shim, Robert F. Vogt
Rok vydání: 2007
Předmět:
Zdroj: British Journal of Haematology. 139:658-662
ISSN: 1365-2141
0007-1048
DOI: 10.1111/j.1365-2141.2007.06842.x
Popis: The pathogenesis of B-cell lymphoproliferative disorders in general and B-cell chronic lymphocytic leukaemia in particular appears to involve dysfunctional regulation of humoral and cellular immunity with the subsequent development of genetic aberrations in B cells. In theory, either component may arise de novo or may be influenced by environmental exposures including infectious agents, antigens, genotoxic chemicals, or radiation. As an intermediary within the exposure-disease continuum, monoclonal B-cell lymphocytosis may be a helpful biomarker for teasing out these various contributions to risk. This article introduces a series of papers that resulted from an International Workshop held in May 2007 entitled 'Monoclonal B-cell Lymphocytosis and Chronic Lymphocytic Leukemia: Environmental and Genetic Risk Factors'. Research efforts, such as those described in this issue, should lead to improved interventions, more predictive biomarkers, more effective treatments, and a greater appreciation of how the immune system functions over the entire human lifespan.
Databáze: OpenAIRE
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