New Studies on the Filtrability of Pure Cultures of the Tubercle Group of Micro-Organisms
| Autor: | L. W. Fisher, Ralph R. Mellon |
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| Rok vydání: | 1932 |
| Předmět: | |
| Zdroj: | Journal of Infectious Diseases. 51:117-128 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/51.1.117 |
| Popis: | The experiments to be reported here have been designed to overcome the last remaining obstacles to the acceptance of the view that the acidfast group of bacteria possess a filtrable phase in their life history. The matter is stated in this way because, as it happens, we have employed chiefly a saprophytic member of the group in the beginning, although the tubercle bacillus itself has shown complete parallelism as far as we have gone. Preliminary communications have already appeared (Mellon1). With the exception of a paper by one of us (Mellon la), in which cultural studies are referred to briefly, there is almost no report of the employment of cultures alone in attempts to demonstrate a filtrable phase with members of this group. In other words, the fact that either negative results or those conditioned by animal passage have followed such essays makes the satisfaction of this criterion a crucial point. Germination of the filtrable gonidia (granules) must be accomplished in vitro, but it is not of paramount importance that they yield directly the original acid-fast stage of the organism, although ultimately this is obviously desirable. However, both of these objectives have been reached and under technical conditions that are believed to be unassailable. |
| Databáze: | OpenAIRE |
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