Synthesis and regioselective alkylation of 1,6- and 1,7-naphthyridines

Autor:	Vincent J. Colandrea, Elizabeth M. Naylor
Rok vydání:	2000
Předmět:	Ethylchloroformate Chemistry Organic Chemistry Drug Discovery Regioselectivity Alkylation Biochemistry Combinatorial chemistry
Zdroj:	Tetrahedron Letters. 41:8053-8057
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)01400-3
Popis:	A regioselective alkylation of naphthyridines 4a–d, through the action of ethylchloroformate and benzylstannane 5, afforded the benzyl substituted dihydronaphthyridines 3a–d. These key intermediates 3a–d were transformed into the desired targets 2a–d in seven steps.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::47d4276b6d9f081d3107fd7a2bee02e2 https://doi.org/10.1016/s0040-4039(00)01400-3 Zobrazit plný text záznamu Full Text from ScienceDirect