Anti-Human Epidermal Growth Factor Receptor 2 Monoclonal Antibody H2Mab-41 Exerts Antitumor Activity in a Mouse Xenograft Model of Colon Cancer
| Autor: | Junko Takei, Shunsuke Itai, Tomokazu Ohishi, Takuro Nakamura, Mika K. Kaneko, Masato Sano, Hiroyuki Harada, Shinji Yamada, Yukinari Kato, Manabu Kawada |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.drug_class Colorectal cancer Immunology Monoclonal antibody 03 medical and health sciences Peritoneal cavity 0302 clinical medicine Trastuzumab medicine Immunology and Allergy skin and connective tissue diseases Antitumor activity Lung 030102 biochemistry & molecular biology biology business.industry medicine.disease medicine.anatomical_structure Cell culture 030220 oncology & carcinogenesis Cancer research biology.protein Antibody business medicine.drug |
| Zdroj: | Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 38:157-161 |
| ISSN: | 2167-9436 |
| Popis: | The expression of human epidermal growth factor receptor 2 (HER2) has been reported to be overexpressed in several cancers, such as breast, lung, gastric, pancreatic, and colorectal cancers, and be associated with poor clinical outcomes. Trastuzumab, a humanized anti-HER2 antibody, provides significant survival benefits for patients with HER2-overexpressing breast cancers and gastric cancers. In this study, we developed a novel anti-HER2 monoclonal antibody (mAb), H2Mab-41 (IgG2b, kappa), and the antitumor activity of H2Mab-41 was investigated using mouse xenograft models. Caco-2 cells (human colon cancer cell line), which expresses HER2, were subcutaneously implanted into the flanks of nude mice. H2Mab-41 and control mouse IgG were injected three times into the peritoneal cavity of mice. H2Mab-41 significantly reduced tumor development of Caco-2 xenograft in comparison with the control mouse IgG on days 5, 8, 11, 15, and 19. Taken together, these results suggest that H2Mab-41 is useful for antibody therapy against HER2-expressing colon cancers. |
| Databáze: | OpenAIRE |
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