Development of L-689,065 - the prototype of a new class of potent 5-lipoxygenase inhibitors

Autor:	L.Y. Choo, Stella Charleson, Petpiboon Prasit, Denis Riendeau, H. Piechuta, Jillian F. Evans, Richard G. Ball, John H. Hutchinson
Rok vydání:	1992
Předmět:	Indole test biology Stereochemistry Chemistry Organic Chemistry Clinical Biochemistry Substituent Pharmaceutical Science Ring (chemistry) Biochemistry chemistry.chemical_compound Drug Discovery Arachidonate 5-lipoxygenase biology.protein Molecular Medicine Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 2:1699-1702
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(00)80459-x
Popis:	The combination of a 5-phenylpyridine substituent and a novel, substituted thiopyrano[2,3,4-c,d]indole ring system yields a potent and selective 5-lipoxygenase inhibitor, L-689,065.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::47c5f17d3be1c5bfbd0eb77be673cbb4 https://doi.org/10.1016/s0960-894x(00)80459-x Zobrazit plný text záznamu