INTRAVENOUS PHARMACOKINETICS OF PENICILLIN G AND ANTIPYRINE IN OSTRICHES (DROMAIUS NOVAEHOLLANDIAE)
| Autor: | Zuncai Wang, A. Alan Kocan, Alistair I. Webb, Cyril R. Clarke, Laura Cudd |
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| Rok vydání: | 2001 |
| Předmět: |
Volume of distribution
medicine.medical_specialty General Veterinary symbols.heraldic_supporter Physiology General Medicine Biology biology.organism_classification Penicillin Endocrinology Pharmacokinetics Internal medicine medicine symbols Dromaius novaehollandiae Animal Science and Zoology Hepatic Elimination medicine.drug Struthio |
| Zdroj: | Journal of Zoo and Wildlife Medicine. 32:74-77 |
| ISSN: | 1042-7260 |
| DOI: | 10.1638/1042-7260(2001)032[0074:ipopga]2.0.co;2 |
| Popis: | Penicillin G and antipyrine, which served as model drugs to assess the relative capacities of renal and hepatic elimination pathways, respectively, were each administered intravenously to six ostriches (Struthio camelus) and to six emus (Dromaius novaehollandiae). Drug concentrations in blood samples collected over a period of 12 hr after administration were assayed, and elimination half-life, mean residence time, clearance, and steady-state volume of distribution were calculated. Mean values for elimination half-life and mean residence time of penicillin G were significantly higher in emus than in ostriches; no significant differences in antipyrine pharmacokinetics between species were demonstrated. |
| Databáze: | OpenAIRE |
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