pH-dependent hydrolysis and drug release of chitosan/polyether interpenetrating polymer network hydrogel

Autor: Mei-xuan Xu, Tao Peng, Kangde Yao, Lei Ren, Qi-qing Zhang, Mattheus F. A. Goosen, Chen Yuan
Rok vydání: 1994
Předmět:
Zdroj: Polymer International. 34:213-219
ISSN: 1097-0126
0959-8103
DOI: 10.1002/pi.1994.210340213
Popis: This paper describes a novel hydrogel based on crosslinked chitosan with glutaraldehyde interpenetrating polyether polymer network. The gel can hydrolyse in acid at 37°C due to the cleavage of imine bonds within the network. At pH≥7, there is no hydrolysis. The pH-dependent release of cimetidine from the gel was also investigated.
Databáze: OpenAIRE