A system of differential scanning calorimetry for the investigation of medicinal preparations

Autor:	S. G. Smelova, S. V. Fedotov, M. L. Tkachenko, Yu. V. Moshchenskii, L. E. Zhnyakina
Rok vydání:	2005
Předmět:	Pharmacology Differential scanning calorimetry Chemistry Thermocouple Drug Discovery Pharmacology toxicology Melting point Analytical chemistry Temperature difference Atmospheric temperature range High potential
Zdroj:	Pharmaceutical Chemistry Journal. 39:610-613
ISSN:	1573-9031 0091-150X
Popis:	A new system for differential scanning calorimetry (DSC) is described, which comprises a DSC setup linked via an interface to an IBM PC provided with specially developed software. The DSC instrument operation is based on the measurement of a local temperature difference with the aid of a disk thermocouple. The new system has been tested by the analysis of model drug mixtures. The results show the expediency and high potential of using DSC for the identification and quality control of drugs. The proposed system allows samples weighing 1–50 mg to be heated at a controlled rate within 0.1–64 K/min in the temperature range from −150 to 500°C. The only limitation is that the DSC method is applicable to substances not exhibiting decomposition at temperatures below the melting point.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::47ae797b6723e86bd53e6930cc16b9be https://doi.org/10.1007/s11094-006-0029-3 Zobrazit plný text záznamu Plný text ve formátu PDF