Bioavailability in rats of bound residues present in liver and intestine of chickens fed diet treated with 3-phenoxybenzoic acid
| Autor: | M. Humayoun Akhtar, Kamal Singh, Shahamat U. Khan, Sam Kacew, Pablo Ocampo |
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| Rok vydání: | 1992 |
| Předmět: |
Kidney
medicine.medical_specialty Environmental Engineering Health Toxicology and Mutagenesis Metabolite Public Health Environmental and Occupational Health General Medicine General Chemistry Urine Biology Pollution Bioavailability chemistry.chemical_compound Residue (chemistry) medicine.anatomical_structure Endocrinology chemistry Biotransformation Oral administration Internal medicine medicine Environmental Chemistry Feces |
| Zdroj: | Chemosphere. 24:745-752 |
| ISSN: | 0045-6535 |
| Popis: | The bioavailability of bound residues generated after exhaustive extraction with methanol from liver and intestine of chickens fed diet treated with 3-phenoxybenzoic acid (3-PB acid) was investigated in rats. 3-PB acid was present in the form of bound residue in liver and intestine of chickens and did not undergo any detectable biotransformation after it was consumed by rats. After six days, 10.2% and 8.5% of the bound residues were eliminated in urine, while 78.7% and 81.6% were voided in feces from rats fed liver and intestine of chickens, respectively. However, about 30–45% of the total 14C in feces was readily extractable with methanol. No 14C residues were detected in liver, kidney, lungs and heart. The data shows that bound residues of 3-PB acid from liver and intestine of chickens are bioavailable to rats. |
| Databáze: | OpenAIRE |
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