Enzymic peroxidation of lipids and oxidative metabolism of chlorpromazine in brain microsomal fraction

Autor:	I. A. Eluashvili, Prilipko Ll, V. E. Kagan
Rok vydání:	1978
Předmět:	Oxygenase Antioxidant Chemistry medicine.medical_treatment Endoplasmic reticulum Lipid metabolism General Medicine Metabolism General Biochemistry Genetics and Molecular Biology Lipid peroxidation chemistry.chemical_compound Biochemistry medicine Microsome Chlorpromazine medicine.drug
Zdroj:	Bulletin of Experimental Biology and Medicine. 86:1321-1324
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00800447
Popis:	Enzymic NADPH-dependent systems of lipid peroxidation and chlorpromazine metabolism were shown to be localized in rat and human brain microsomal fractions (BMF). Hydroxy-derivatives of chlorpromazine [7-hydroxychlorpromazine (7-OH)] formed as a result of enzymic NADPH-dependent metabolism possess antioxidant action and inhibit enzymic peroxidation of lipids (POL) in brain microsomes. The properties of enzymic NADPH-dependent oxygenase systems in the membranes of the endoplasmic reticulum of the liver and BMF are compared.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::47a25121fdcc9db6b5854b3309165aaf https://doi.org/10.1007/bf00800447 Zobrazit plný text záznamu Full text from SpringerLink