COVID-19 during pregnancy should we really worry from vertical transmission or rather from fetal hypoxia and placental insufficiency? A systematic review and meta -analysis
| Autor: | Yasmin Omar, Rama Darwish, Rana Essam, Dalia Habib, Samer Khaldi, Noura Shebl, Sama Ahmed, Monica Ibrahim, Antoine Fakhry AbdelMassih, Marian AbdelMassih, Sadra Albala, Habiba-Allah Ismail, Alhussein Negm, Marina Ibrahim, Salwa Imran, Maram Hanafy, Hadeer Aly, Sara Abohashish, Ibrahim Genedy, Rana Ramadan, Leena Makki, Stavro Paulo, Mohamed Ebaid, Rahma Menshawey, Dalia H Khalil, Mourad Alfy Tadros, Rana ElShahawi, Layla El Qadi, Raghda Fouda, Maha Shulqamy, Nirvana Ashraf, George Afdal, Nadine El-Husseiny |
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| Rok vydání: | 2020 |
| Předmět: |
Pregnancy
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) business.industry Obstetrics media_common.quotation_subject Placental insufficiency medicine.disease law.invention Fetal hypoxia Transmission (mechanics) Text mining law Meta-analysis medicine Worry business psychological phenomena and processes media_common |
| Popis: | Background:COVID-19 is the largest outbreak to strike humanity. The wide scale of fatalities and morbidities lead to a concurrent pandemic of uncertainty in scientific evidence. Conflicting evidences are released on daily basis about the neonatal outcomes of COVID-19 positive mothers. The aim of this study was to use the relevant case reports and series to determine the percentage of newborns who test positive in COVID-19 positive mothers. Secondary outcomes included examining laboratory and placental abnormalities among fetus-mother pairs.Methods:Systematic review was performed on all studies reporting primary data on fetus-mother pairs with COVID-19. Data bases were searched for studies that met our inclusion and exclusion criteria.Results: Final screening revealed 66 studies, from which the primary data of 1787 mother-infant pairs was obtained. Only 2.8% of mother infant pairs were tested positive, and this finding is identical to percentages reported in former coronaviridae outbreaks. Whereas, 20% manifested with intrauterine hypoxia alongside placental abnormalities suggestive of heavy placental vaso-occlusive involvement. Conclusions: These findings suggest that while vertical transmission is unlikely, there appears to be an underlying risk of placental insufficiency due to the prothrombotic tendency observed in COVID-19 infection. Guidelines for proper prophylactic anticoagulation in COVID positive mothers need to be established. |
| Databáze: | OpenAIRE |
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