Aerobic exercise reduces lung inflammation and fibrosis mediated by serotoninergic/Akt signaling in a model of pulmonary fibrosis
| Autor: | Ana Paula Ligeiro de Oliveira, Nilsa Regina Damaceno-Rodrigues, Humberto Dellê, Oliver Eickelberg, Hugo C. Castro-Faria-Neto, Paulo Rogério Pereira, Marco Idzko, Marisa Dolhnikoff, Flavia R. Greiffo, Yves Silva Teles Matos, Thayse Regina Brugemman, Rodolfo de Paula Vieira, Ana Roberta Almeida-Oliveira, Adilson Santos Andrade-Sousa, Manoel Carneiro Oliveira-Junior, Nicole Cristine Rigonato-Oliveira, Regiane Albertini, Isis E. Fernandez |
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| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Lung medicine.diagnostic_test business.industry respiratory system Lung injury medicine.disease Bleomycin respiratory tract diseases chemistry.chemical_compound Idiopathic pulmonary fibrosis Bronchoalveolar lavage medicine.anatomical_structure chemistry Fibrosis Pulmonary fibrosis medicine Aerobic exercise business |
| Zdroj: | 1.2 Rehabilitation and Chronic Care. |
| Popis: | Idiopathic pulmonary fibrosis (IPF) is characterized by decline of lung function, inflammation and fibrosis, with serotonin (5-HT) and Akt signaling presenting a key role. Aerobic training (AT) reduces lung injury in models of pulmonary diseases. However, the mechanisms underlying the effects of AT in a model of bleomycin-induced lung fibrosis is unknown. Thus, this study investigated the effects of AT in a model of bleomycin-induced pulmonary fibrosis, as well as the participation of 5HT/Akt signaling. Seventy-two C57Bl/6 male mice were distributed in Control (Co), Exercise (Ex), Fibrosis (Fi) and Fibrosis+Exercise (Fi+Ex) groups. Bleomycin (1.5UI/Kg) was administered on day 1 and treadmill AT began on day 14 during 4 weeks. Total and differential cells count in bronchoalveolar lavage (BAL), IL-1beta, IL-6, CXCL1/KC, IL-10, TNF-alpha and TGF-beta levels in BAL fluid, collagen content in the lung parenchyma, 5-HT levels in BAL fluid and in serum, and the expression of 5-HT2b receptor and Akt were evaluated. AT reduced bleomycin-induced number of total cells (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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