| Popis: |
The solubilizing potential and complexing tendencies of six cyclodextrins (CyD) with nifedipine in aqueous solution were evaluated using phase solubility methods. Solubility curves of nifedipine with β-CyD, 2-hydroxypropyl-β-CyD (2HP-β-CyD) and 2-hydroxypropyl-γ-cyclodextrin (2HP-γ-CyD) were classified as type AL, while for heptakis (2, 6-dimethyl)β-CyD (DIMEB), randomly methylated-β-CyD (RAMEB) and γ-CyD, AP type phase behaviour was observed. Stability constants, calculated from phase solubility diagrams, decreased in the order: DIMEB > RAMEB > β-CyD > 2HP-β-CyD > γ-CyD > 2HP-γ-CyD. |
