Synthesis, Antifungal Activity, and SAR Study of Some New 6-Perfluoropropanyl Quinoline Derivatives
| Autor: | Shen Zhonghua, Rui-Rui Zhang, Xing-Hai Liu, Wu Hongke, Cheng-Xia Tan, Jian-Quan Weng, Yue-Ming Fang, Tian-Ming Xu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Antifungal
Pyricularia biology 010405 organic chemistry medicine.drug_class Stereochemistry Organic Chemistry Quinoline Good control biology.organism_classification 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry medicine Bioassay Molecule Moiety Control effect |
| Zdroj: | Journal of Heterocyclic Chemistry. 55:240-245 |
| ISSN: | 0022-152X |
| DOI: | 10.1002/jhet.3031 |
| Popis: | A series of novel quinoline derivatives containing perfluoropropanyl moiety were designed and synthesized. The bioassay results showed that some of them exhibited good control efficacy against Pyricularia oryae. The fungicidal activity was affected by the substituted position in the molecule. It was found that the compound 3n possessed highest control effect against P. oryae at different concentration. It is better than that of control Tebufloquin. |
| Databáze: | OpenAIRE |
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