| Popis: |
Glimepiride is a third-generation sulfonylurea of oral antidiabetic with poorly water-soluble. It is necessary to improve its solubility of glimepiride in the Self-Nano Emulsifying Drug Delivery System (SNEDDS) formulation. This research aims to optimize of glimepiride in SNEEDS formulation prepared using oleic acid as a lipid carrier. The D-Optimal experimental design was used for the optimization of glimepiride SNEDDS formulations. SNEDDS loaded glimepiride was characterized includes transmittance, particle size, polydispersity index (PDI), zeta potential, and drug content as the dependent variable. In contrast, the independent variables are oleic acid, tween 20, and PEG 400 as lipids, surfactants, and co-surfactants. The optimum result of the SNEDDS formula was obtained that the optimum composition was 10% oleic acid, tween 20 60%, and PEG 400 30%. The characterization showed that 99.34 ± 0,01% of transmittance, 29,3 ± 0,1 nm of particle size, 0.399 ± 0.045 of PDI, 34.01 ± 0.91mV of zeta potential. The content of glimepiride in SNEDDS preparations is 100.81 ± 3.68%. The predicted particle size, according to D-Optimum, was 29.61 nm, while the observation result was 29.3 ± 0.1 nm. It can be concluded that D-Optimal experimental design can be used to optimize the glimepiride in SNEDDS formulation with a bias of 0.74%. |
