Autor: |
M. Paglialunga Paradisi, G. Pagani Zecchini, Gino Lucente, Ines Torrini, Susanna Spisani, Marianna Nalli |
Rok vydání: |
2001 |
Předmět: |
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Zdroj: |
The Journal of Peptide Research. 58:56-66 |
ISSN: |
1397-002X |
DOI: |
10.1034/j.1399-3011.2001.00875.x |
Popis: |
In order to further examine the properties of pseudopeptides containing the 2-hydrazonoacyl fragment, two new series of analogs of the prototypical chemotactic N-formyl-tripeptide HCO-Met-Leu-Phe-OMe were designed and synthesized. The first group contains the new fragment as the N-terminal residue and is represented by the N-aryl derivatives p-Cl-C6H4-NH-N=C(R)-CO-Leu-Phe-OMe (2 and 3) and by the corresponding N-aroyl analogs p-CH3-C6H4-CO-NH-N=C(R)-CO-Leu-Phe-OMe (4). The second group contains the new fragment in place of the central Leu residue and is represented by compounds HCO-Xaa-NH-N=C(R)-CO-Phe-OMe (7a and 7b) where Xaa is Nle and Met, respectively. The conformational and biochemical properties of the new products were examined. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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