Soluble Amyloid-β Protein Aggregates Induce Nuclear Factor-κB Mediated Upregulation of Adhesion Molecule Expression to Stimulate Brain Endothelium for Monocyte Adhesion
| Autor: | J. Will Reed, Francisco J. Gonzalez-Velasquez, Melissa A. Moss, Joseph A. Kotarek, John W. Fuseler, Deborah D. Soto-Ortega, Emily E. Matherly |
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| Rok vydání: | 2010 |
| Předmět: |
Materials science
Cell adhesion molecule Intercellular Adhesion Molecule-1 Soluble cell adhesion molecules Surfaces and Interfaces General Chemistry Adhesion Intercellular adhesion molecule Surfaces Coatings and Films Cell biology Endothelial stem cell Mechanics of Materials Materials Chemistry Neural cell adhesion molecule Cell adhesion |
| Zdroj: | Journal of Adhesion Science and Technology. 24:2105-2126 |
| ISSN: | 1568-5616 0169-4243 |
| DOI: | 10.1163/016942410x507948 |
| Popis: | The adhesion of circulating monocytes to cerebrovascular endothelium has the potential to contribute to the pathogenesis of Alzheimer's disease (AD). In AD, the amyloid-β protein (Aβ) assembles to form fibrils that deposit within both the brain parenchyma and the cerebrovasculature. Soluble Aβ aggregates, intermediates on the pathway to mature fibril formation, are responsible for the stimulation of brain microvascular endothelial cells for increased adhesion of monocytes. However, a related role for soluble Aβ aggregates in the upregulation of endothelial cell surface adhesion molecules that support monocyte adhesion remains to be demonstrated. The current study establishes that upregulation of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) on the surface of human brain microvascular endothelial cells is selectively induced by soluble Aβ 1-40 aggregates, while unaggregated monomer and mature fibril fail to elicit a substantial increase in adhesion molecule expre... |
| Databáze: | OpenAIRE |
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