Structure-based design of novel, dipeptide ligands targeting the pp60Src SH2 domain
| Autor: | Tomi K. Sawyer, Kimberly Suzanne Para, Alan R. Saltiel, Debra R. Holland, James S. Marks, James H. Fergus, Elizabeth A. Lunney, J. R. Rubin, Christine Humblet, Aurash Shahripour, Mark Stephen Plummer |
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| Rok vydání: | 1997 |
| Předmět: |
Dipeptide
Stereochemistry Phosphopeptide Ligand Organic Chemistry Clinical Biochemistry Pharmaceutical Science Tripeptide SH2 domain Biochemistry Chemical synthesis Combinatorial chemistry chemistry.chemical_compound chemistry Drug Discovery Peptide synthesis Molecular Medicine Molecular Biology Proto-oncogene tyrosine-protein kinase Src |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 7:1107-1112 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(97)00190-x |
| Popis: | Based on the X-ray structures of the pp60Src (Src) SH2 domain complexed with two high affinity phosphopeptide ligands (Glu-Pro-Gln-pTyr-Glu-Glu-Ile-Pro-Ile-Tyr-Leu, and Ac-pTyr-Glu- D -Hcy-NH2; Hcy = homocyclohexylalanine), we report herein the design and structure-activity relationships of a series of novel dipeptide ligands targeting the Src SH2 domain. |
| Databáze: | OpenAIRE |
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