Association of caveolin-1 protein expression with hepatocellular carcinoma: a meta-analysis and literature review
| Autor: | Yan Zhang, Jinglong Dong, Zhanjun Cui, Wenjuan Fan, Jiang Wu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cirrhosis business.industry medicine.disease medicine.disease_cause digestive system diseases Protein expression Pathogenesis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Meta-analysis Hepatocellular carcinoma Caveolin 1 cardiovascular system Cancer research medicine business Carcinogenesis Protein overexpression |
| Zdroj: | Cancer Management and Research. 11:5113-5122 |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s194033 |
| Popis: | Background: Aberrant expression of caveolin-1 (CAV-1) is involved in the pathogenesis of hepatocellular carcinoma (HCC); however, the results have been inconsistent due to the small size of sample in the individual study. Methods: We performed a meta-analysis and evaluated the association of CAV-1 protein overexpression and clinicopathological significance by using Review Manager 5.2. Pooled ORs and HR with corresponding CIs were calculated. Results: Nine studies were included in the meta-analysis with 810 HCC and 172 cirrhosis patients. CAV-1 protein overexpression was correlated with the risk of cirrhosis; OR was 3.25, p=0.01. Furthermore, the rate of CAV-1 protein overexpression was significantly higher in HCC with cirrhosis than HCC without cirrhosis, suggesting that the CAV-1 protein overexpression likely initiated carcinogenesis in liver with cirrhosis and subsequently contributed to the progression of HCC. In addition, CAV-1 protein overexpression was strongly associated with poor differentiated HCC and invasion; ORs were 2.61 and 2.71, respectively. CAV-1 protein overexpression was strongly correlated with poor overall survival in patients with HCC; HR was 0.4, p=0.03. Conclusions: In summary, CAV-1 protein overexpression is at risk for liver cirrhosis and HCC derived from cirrhosis, and CAV-1 is also a promising prognostic predictor in HCC. |
| Databáze: | OpenAIRE |
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