The paradoxical association of common polymorphisms of the renin-angiotensin system genes with risk of myocardial infarction
| Autor: | Fotios G. Kardaras, Dimitri J. Richter, Pavlos Toutouzas, Stefanos G. Foussas, Evaggelos G. Papasteriadis, Michalis N. Zairis, Christodoulos Stefanadis, Paraskeui G. Vogiatzi, John Gialafos, George Andrikopoulos, R.K. Mattu, Gemig study investigators, Edward W. Needham, Elias Gialafos, Stylianos E. Tzeis |
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| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Univariate analysis Angiotensin II receptor type 1 Epidemiology business.industry medicine.disease Coronary artery disease Endocrinology Internal medicine Diabetes mellitus Genotype medicine Population study Myocardial infarction Family history Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Journal of Cardiovascular Prevention & Rehabilitation. 11:477-483 |
| ISSN: | 1741-8275 1741-8267 |
| Popis: | BackgroundThe insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) and the A1166C polymorphism of the angiotensin-II AT1 receptor (AT1R) have been extensively investigated as possible risk factors for myocardial infarction (MI).Design and methodsGenetic association, case-control study, specifically designed to investigate the association of the above-mentioned polymorphisms with risk of MI in a homogeneous, low coronary risk, Caucasian population. The study population consisted of 1603 consecutive patients with acute MI who were recruited from nine clinics, located in three cities, and 699 unrelated adults who were randomly selected from the city catalogues.ResultsIn univariate analysis, the DD genotype was found to be more prevalent among controls (40.8 vs. 35.2%, P = 0.011). In multivariate analysis adjusted for age, gender, smoking status, diabetes mellitus, hypercholesterolemia, hypertension and family history of coronary artery disease, the presence of the DD genotype was indepe... |
| Databáze: | OpenAIRE |
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