Thiolation of Pyridine-2-sulfonamides using Magnesium Thiolates

Autor:	Benjamin Heinz, Moritz Balkenhohl, Paul Knochel
Rok vydání:	2019
Předmět:	Range (particle radiation) Quenching (fluorescence) 010405 organic chemistry Magnesium Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Pyridine Electrophile Polymer chemistry
Zdroj:	Synthesis. 51:4452-4462
ISSN:	1437-210X 0039-7881
Popis:	The thiolation of pyridine-2-sulfonamides using magnesium thiolates is reported. The ortho-functionalizations of these sulfonamides using TMPMgCl·LiCl (TMP = 2,2,6,6-tetramethylpiperidyl) followed by electrophilic quenching produced a range of 3-functionalized pyridine-2-sulfonamides, which were subsequently converted into the corresponding thioethers. Finally, symmetric or asymmetric diorganodisulfides were employed as electrophiles in a one-pot ortho-functionalization–thiolation procedure, leading to pyridine 2,3-disubstituted dithioethers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::474cfd04699354a19f473904dfc344ce https://doi.org/10.1055/s-0039-1690199 Zobrazit plný text záznamu