Synthesis and muscarinic acetylcholine receptor (mAChR) antagonist activity of substituted piperazine-triazoles
| Autor: | Sabita Nayak, Kshetra Pal Singh, B. N. Acharya, Ramarao Ghorpade, Deo Kumar |
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| Rok vydání: | 2021 |
| Předmět: |
010405 organic chemistry
Chemistry Antagonist Triazole Ileum General Chemistry Pharmacology 010402 general chemistry 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Piperazine Benzonitrile medicine.anatomical_structure Muscarinic acetylcholine receptor medicine Neurotransmitter Ex vivo |
| Zdroj: | Monatshefte für Chemie - Chemical Monthly. 152:357-366 |
| ISSN: | 1434-4475 0026-9247 |
| DOI: | 10.1007/s00706-021-02752-4 |
| Popis: | This study describes synthesis of a series of piperazine-triazole derivatives and their ex vivo evaluation for preliminary muscarinic acetylcholine receptor (mAChR) blocking activity on rat ileum model. A molecule based on benzonitrile piperazine triazole scaffold showed good tissue relaxation and blocking of neurotransmitter ACh in the ex vivo experiment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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