| Autor: |
Chittaranjan S. Yajnik, Rucha H. Wagh, Bjerregaard-Andersen M, Hennild De, Bandyopadhyay S, Stine Byberg, G. M. Gomes, Kaare Christensen, Pranav Yajnik, Rashmi B. Prasad, Morten Sodemann, Møller Jensen D |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
‘Thrifty phenotype’ hypothesis proposed that fetal undernutrition increases risk of diabetes in later life. Undernourished low birthweight Indian babies are paradoxically more adipose compared to well-nourished European babies, and are at higher risk of diabetes in later life. Twin pregnancies are an example of in utero growth restrictive environment due to shared maternal nutrition. There are few studies of body composition in twins. We performed secondary analysis of anthropometric body composition of twins and singletons in Guinea-Bissau, an economically deprived African country.Anthropometric data was available on 7–34 year-old twins (n=209, 97 males) and singletons (n=182, 86 males) in the Guinea-Bissau Twin Registry at the Bandim Health Project. Twins had lower birth weight (2420 vs 3100 g, pAfrican populations are known to have a muscular (less adipose) body composition. Demonstration of a thin-fat phenotype in twins in a low socioeconomic African country supports the thesis that it could be a manifestation of early life undernutrition and not exclusive to Indians. This phenotype could increase risk of diabetes and related conditions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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