Caffeine as an aid to sodium pentobarbital analgesia in labor
| Autor: | August F. Daro, Philip J. Stein |
|---|---|
| Rok vydání: | 1942 |
| Předmět: |
Drug
business.industry medicine.medical_treatment media_common.quotation_subject Obstetrics and Gynecology Amnesia Sodium pentobarbital Stimulant chemistry.chemical_compound Action (philosophy) chemistry Anesthesia Obstetric analgesia medicine medicine.symptom business Caffeine Confusion media_common |
| Zdroj: | American Journal of Obstetrics and Gynecology. 43:94-98 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/s0002-9378(42)91338-3 |
| Popis: | The search for the ideal drug or combination of drugs for obstetric analgesia and amnesia has been long and arduous. It has been stated that the proper drugs have not been discovered. In recent years however, the barbiturates have given promise of fulfilling the varied requirements for ideal effect. Sodium pentobarbital in particular seems to be the most likely of the many preparations that have been tried. Nevertheless, and notwithstanding many clinical studies which emphasize the favorable results attained by the use of sodium pentobarbital alone or in combination, there still remain certain objectionable features, viz.: the confusion, restlessness, and maniacal states which this drug may cause. In the most recent review of the progress of the barbiturates in obstetric analgesia, Hellman 1 points out that "the chief objection to all analgesia technics has been, and remains today, the excitatory action of the drugs. … The future development of obstetric analgesia seems to depend on the discovery of compounds whose action is less excitant and whose effects are more controllable." Since experiments with new and different barbiturates have not been promising, another combination of drugs was sought. At the suggestion of the late Dr. Bernard Fantus, to whom the objectionable features of sodium pentobarbital analgesia were outlined, we decided to add caffeine, a mild cerebral stimulant, to the drug. Thus the delirium of the mother which may be due to a cutting-off of the control of the voluntary cerebral impulses might be counteracted by the mild cerebral stimulation of caffeine. The purpose of this paper is to report the results of these experiments. While the number of cases is not large, it is a well-selected and controlled group and reflects the valuable contributory action of this cerebral stimulant; it also intimates that other, more powerful, cerebral stimulants might be valuable adjuncts. We hope that it will open new vistas into the future progress of obstetric analgesia. |
| Databáze: | OpenAIRE |
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