| Popis: |
Summary Feeding experiments with tryptophan tritiated stereospecifically at C-3 indicate that the C methylation at the methylene group of indolepyruvate, an early step in the biosynthesis of the antibiotic indolmycin, proceeds stereospecifically with retention of configuration. L-Arginine-[amidino- 14 C, 15 N] is incorporated into indolmycin without change in the 15 N/ 14 C ratio, and this as well as-the intramolecular 15 N distribution in precursor and product suggests transfer of an intact amidino group from arginine to form the oxazolinone ring of the antibiotic. |
