Influence of Moxonidine and Bisoprolol on Morphofunctional Condition of Arterial Wall and Telomerase Activity in Postmenopausal Women with Arterial Hypertension and Osteopenia. The Results from a Moscow Randomized Study
| Autor: | Ekaterina N. Dudinskaya, E V Bazaeva, Olga N. Tkacheva, Larina Vn, K. A. Eruslanova, N. V. Sharashkina, Yu. V. Kotovskaya, Lubov Matchekhina |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
medicine.medical_specialty Moxonidine business.industry Osteoporosis General Medicine medicine.disease law.invention Osteopenia Blood pressure Randomized controlled trial Bisoprolol law Internal medicine medicine Arterial stiffness Cardiology Pharmacology (medical) Cardiology and Cardiovascular Medicine business Pulse wave velocity medicine.drug |
| Zdroj: | Cardiovascular Drugs and Therapy. 36:1147-1155 |
| ISSN: | 1573-7241 0920-3206 |
| Popis: | To compare the effect of 12 months of treatment with moxonidine or bisoprolol on telomerase activity (TA) and parameters characterizing the arterial wall state in postmenopausal women with arterial hypertension (AH) and osteopenia. An open-label randomized study with 114 postmenopausal women with hypertension and osteopenia; pulse wave velocity (PWV), intima-media thickness (IMT), and TA were analyzed initially and after 12 months of therapy with moxonidine (n = 57) or bisoprolol (n = 57). Both medications effectively lowered blood pressure (BP) in both groups. After 12 months, the moxonidine group showed a significant increase in TA by 45.5% (from 0.87 to 1.15; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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