Risk factors for locoregional relapse after transoral robotic surgery for human papillomavirus-related oropharyngeal squamous cell carcinoma
| Autor: | Eric J. Moore, Joaquin J. Garcia, Daniel J. Ma, Eneida F. Vencio, W. Scott Harmsen, Ryan K. Funk, David G. Stoddard, Robert L. Foote, Katharine A. Price |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
medicine.medical_specialty biology business.industry medicine.medical_treatment Retrospective cohort study biology.organism_classification 03 medical and health sciences 0302 clinical medicine Oropharyngeal Neoplasm Otorhinolaryngology 030220 oncology & carcinogenesis Internal medicine Transoral robotic surgery medicine Adjuvant therapy 030212 general & internal medicine Papillomaviridae Oropharyngeal squamous cell carcinoma Human papillomavirus business Adjuvant |
| Zdroj: | Head & Neck. 38:E1674-E1679 |
| ISSN: | 1043-3074 |
| Popis: | Background Factors predicting locoregional relapse after surgery for oropharyngeal squamous cell carcinoma (SCC) were identified in the pre-human papillomavirus (HPV) era. We examined whether traditional indications for adjuvant radiotherapy (RT) or adjuvant chemoradiotherapy (CRT) still correlate with locoregional relapse in HPV-positive patients after transoral robotic surgery (TORS). Methods Retrospective review of oropharyngeal SCC cases identified patients with HPV-positive tumors who did not receive adjuvant therapy after TORS despite intermediate or high-risk features. Results Median follow-up was 26.7 months (range, 4.9–73.1 months). Five of 25 eligible patients (20%) relapsed at a median 4.8 months (range, 3.2–7.8 months). Two of 18 (11%) intermediate and 3 of 7 (43%) high-risk patients relapsed. Kaplan–Meier 2-year locoregional relapse-free survival estimates for intermediate and high-risk patients were 88% and 57% (p = .078), respectively. Conclusion Traditional indications for adjuvant RT or CRT were associated with high risk of locoregional relapse in HPV-positive patients treated with TORS alone. © 2015 Wiley Periodicals, Inc. Head Neck, 2015 |
| Databáze: | OpenAIRE |
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